Synthesis and Reactions of Isoquinoline Derivatives III. Synthesis and Reactions of 3,4-Dihalogeno-1-phenylisoquinolines

DOI: 10.1055/s-1988-27670

Source and publish data:

Synthesis p. 683 - 685 (1988)

Update date:2022-08-04

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Authors:

Renger, B.

Konz, E.

Rueger, W.

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Article abstract of DOI:10.1055/s-1988-27670

Reaction of 1-phenyl-1,4-dihydro-3(2H)isoquinolinone (1) with phosphorus pentahalides as well as a two-step procedure involving a Vilsmeier-Haack acylation of 1 followed by oxidative cleavage with sodium hypohalites make 3,4-dihalogeno-1-phenylisoquinolines easily available.

Full text of DOI:10.1055/s-1988-27670

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