AN IMPROVED AND EFFICIENT SYNTHESIS OF 2-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES VIA REGIOSPECIFIC BROMINATION

DOI: 10.1016/S0040-4039(00)88453-1

Source and publish data:

Tetrahedron Letters p. 6835 - 6838 (1988)

Update date:2022-09-26

Topics:

Authors:

Sircar, I.

Anderson, K.R.

Bonadies, L.

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Article abstract of DOI:10.1016/S0040-4039(00)88453-1

A highly regioselective conversion of DHP I to DHP II has been achieved for the first time in high yield.Treatment of the bromide II with different nucleophiles under basic conditions produced 2-substituted 1,4-dihydropyridines in high yields and purity.

Full text of DOI:10.1016/S0040-4039(00)88453-1

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