Journal of Medicinal Chemistry p. 10958 - 10971 (2012)
Update date:2022-08-05
Topics:
Koehler, Michael F. T.
Bergeron, Philippe
Blackwood, Elizabeth
Bowman, Krista K.
Chen, Yung-Hsiang
Deshmukh, Gauri
Ding, Xiao
Epler, Jennifer
Lau, Kevin
Lee, Leslie
Liu, Lichuan
Ly, Cuong
Malek, Shiva
Nonomiya, Jim
Oeh, Jason
Ortwine, Daniel F.
Sampath, Deepak
Sideris, Steve
Trinh, Lan
Truong, Tom
Wu, Jiansheng
Pei, Zhonghua
Lyssikatos, Joseph P.
Selective inhibitors of mammalian target of rapamycin (mTOR) kinase based upon saturated heterocycles fused to a pyrimidine core were designed and synthesized. Each series produced compounds with Ki < 10 nM for the mTOR kinase and >500-fold sel
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