Nucleophilic alkenoylation of aldehydes with metalated α- aminonitriles: Regioselective synthesis of α-hydroxyenones

Article abstract of DOI:10.1016/S0040-4039(99)00953-3

An efficient regioselective two-step synthesis of α-hydroxyenones 3a-p is reported. The methodology involves nucleophilic addition of metalated β,γ-unsaturated-α-aminonitriles to aldehydes, followed by a mild silver nitrate induced hydrolysis of the amino