3'-Fluoro-2',3'-dideoxy-5-chlorouridine: most selective anti-HIV-1 agent among a series of new 2'- and 3'-fluorinated 2',3'-dideoxynucleoside analogues.

DOI: 10.1021/jm00128a013

Source and publish data:

Journal of medicinal chemistry p. 1743 - 1749 (1989)

Update date:2022-08-02

Topics:

Authors:

Van Aerschot

Herdewijn

Balzarini

Pauwels Pauwels

De Clercq

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Article abstract of DOI:10.1021/jm00128a013

A series of 2'- and 3'-fluorinated 2',3'-dideoxynucleosides and 3'-azido-2',3'-dideoxynucleosides were synthesized and evaluated for their inhibitory activity against human immunodeficiency virus-1 (HIV-1) replication in MT-4 cells. Neither conversion of

Full text of DOI:10.1021/jm00128a013

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