Total synthesis of (-)-codonopsinol and (+)-2-epi codonopsinol via acid catalyzed amido cyclisation

Article abstract of DOI:10.1016/j.tet.2009.12.035

A short and stereoselective synthesis of (-)-codonopsinol 5 and its C-2 epimer 6 were accomplished from commercially available starting material d-1,5-gluconolactone, using acid mediated amido cyclisation as the key step. The inhibitory activitiy of these