Bioorganic and Medicinal Chemistry Letters p. 5158 - 5161 (2009)
Update date:2022-08-05
Topics: Inhibitors 2-aminobenzimidazoles X-ray crystallography Dose-Response Curve Potent Experimental Kinase assay Aurora kinase Cell proliferation assay
Zhong, Min
Bui, Minna
Shen, Wang
Baskaran, Subramanian
Allen, Darin A.
Elling, Robert A.
Flanagan, W. Michael
Fung, Amy D.
Hanan, Emily J.
Harris, Shannon O.
Heumann, Stacey A.
Hoch, Ute
Ivy, Sheryl N.
Jacobs, Jeffrey W.
Lam, Stuart
Lee, Heman
McDowell, Robert S.
Oslob, Johan D.
Purkey, Hans E.
Romanowski, Michael J.
Silverman, Jeffrey A.
Tangonan, Bradley T.
Taverna, Pietro
Yang, Wenjin
Yoburn, Josh C.
Yu, Chul H.
Zimmerman, Kristin M.
O'Brien, Tom
Lew, Willard
This Letter describes the discovery and key structure-activity relationship (SAR) of a series of 2-aminobenzimidazoles as potent Aurora kinase inhibitors. 2-Aminobenzimidazole serves as a bioisostere of the biaryl urea residue of SNS-314 (1c), which is a
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