Synthesis of acyclonucleoside hydroxamic acids as inhibitors of ribonucleotide reductase

DOI: 10.1021/jm00128a032

Source and publish data:

Journal of Medicinal Chemistry p. 1879 - 1885 (1989)

Update date:2022-08-05

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Authors:

Farr Farr

Bey Bey

Sunkara Sunkara

Lippert Lippert

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Article abstract of DOI:10.1021/jm00128a032

N-Hydroxy-α-(2-hydroxyethoxy)-1(2H)-pyrimidineacetamides 1-3 were synthesized as potential antitumor agents whose mechanism of action would involve inhibition of ribonucleoside diphosphate reductase (RDPR, EC 1.17.4.1). Acyclonucleoside esters 6-8 were pr

Full text of DOI:10.1021/jm00128a032

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