Synthesis of acyclonucleoside hydroxamic acids as inhibitors of ribonucleotide reductase

DOI: 10.1021/jm00128a032

Source and publish data:

Journal of Medicinal Chemistry p. 1879 - 1885 (1989)

Update date:2022-08-05

Topics:

Authors:

Farr Farr

Bey Bey

Sunkara Sunkara

Lippert Lippert

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00128a032

N-Hydroxy-α-(2-hydroxyethoxy)-1(2H)-pyrimidineacetamides 1-3 were synthesized as potential antitumor agents whose mechanism of action would involve inhibition of ribonucleoside diphosphate reductase (RDPR, EC 1.17.4.1). Acyclonucleoside esters 6-8 were pr

Full text of DOI:10.1021/jm00128a032

Products guided by the article

Product name:(2-Benzyloxy-ethoxy)-hydroxy-acetic acid methyl ester

Cas No:121653-72-3

R&D Labs maybe for 121653-72-3

TIANJIN FESTO CHEMICAL CO.,LTD(expird)

Contact:86-22-25814570

Address:No.12th,5th Ave.,TEDA,Tianjin,China
Jiaxing Barton Chemicals

website:http://www.chinabarton.com

Contact:+86-573-82719618

Address:No. 162 Fumin Road, Honghe Town,
Neworld Chemical Co., Ltd Shanghai(expird)

Contact:+86-21-62202658

Address:11F, Blvd 2, No. 1969 PuXing Rd, Shanghai
Changzhou BaoKang Pharmaceutical & Chemical Co., Ltd

Contact:(86) 519-88782201 88784080 88785278

Address:Henglin town, changzhou,Jiangsu
SINO Industries Company Limited(expird)

Contact:86-29-85369724

Address:No.111, Jiefang Road, Xi’an, China

Relevant to this article

Highly enantioselective Michael Addition of α-Substituted Cyano Ketones to β,γ-unsaturated α-keto esters using bifunctional thiourea-tertiary amine catalysts: An easy access to chiral dihydropyrans

Doi:10.1002/adsc.200900516
(2009)
Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists

Doi:10.1016/j.bmcl.2013.01.062
(2013)
Interrupted Polymerization of Acrylates: Sequential Michael-Michael-Dieckmann Cyclizations for Easy, One-Pot, 2 + 2 + 2 Construction of Polyfunctionalized Cyclohexanones

Doi:10.1021/jo00276a002
(1989)
Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors

Doi:10.1016/j.bmcl.2013.02.065
(2013)
Synthesis and Structure of 2α-Hydroxytropan-3-one

Doi:10.1021/jo00277a055
(1989)
Rates and Regioselectivities of the Palladium-Catalyzed Ethynylation of Substituted Bromo- and Dibromobenzenes

Doi:10.1021/jo00279a040
(1989)

Article Doi