Synthesis of 1,4-Thiazepine Derivatives Having Angiotensin-Converting Enzyme Inhibitory Property

DOI: 10.1246/cl.1989.137

Source and publish data:

Chemistry Letters p. 137 - 140 (1989)

Update date:2022-08-05

Topics:

Authors:

Yanagisawa, Hiroaki

Ishihara, Sadao

Ando, Akiko

Kanazaki, Takuro

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Article abstract of DOI:10.1246/cl.1989.137

Reduction of (6R)-6-amino-6,7-dihydro-2-thienyl-1,4-thiazepin-5(4H)-one derivatives with Mg-MeOH gave the corresponding perhydrothiazepinones.Protection with trityl group at the 6-amino group gave predominantly the 2S,6R isomer which was converted to the

Full text of DOI:10.1246/cl.1989.137

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Product name:(2R,6R)-2-Thiophen-2-yl-6-(trityl-amino)-[1,4]thiazepan-5-one

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