Bioorganic and Medicinal Chemistry Letters p. 857 - 861 (2010)
Update date:2022-08-05
Topics:
Beaulieu, Pierre L.
Jolicoeur, Eric
Gillard, James
Brochu, Christian
Coulombe, Rene
Dansereau, Nathalie
Duan, Jianmin
Garneau, Michel
Jakalian, Araz
Kuehn, Peter
Lagace, Lisette
LaPlante, Steven
McKercher, Ginette
Perrault, Stephane
Poirier, Martin
Poupart, Marc-Andre
Stammers, Timothy
Thauvette, Louise
Thavonekham, Bounkham
Kukolj, George
SAR studies at the N1-position of allosteric indole-based HCV NS5B inhibitors has led to the discovery of acetamide derivatives with good cellular potency in subgenomic replicons (EC50 <200 nM). This class of inhibitors displayed improved physicochemical properties and favorable ADME-PK profiles over previously described analogs in this class.
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