ACS Medicinal Chemistry Letters p. 175 - 179 (2010)
Update date:2022-08-05
Topics:
Yin, Yan
Cameron, Michael D.
Lin, Li
Khan, Susan
Schroeter, Thomas
Grant, Wayne
Pocas, Jennifer
Chen, Yen Ting
Schuerer, Stephan
Pachori, Alok
Lograsso, Philip
Feng, Yangbo
A series of urea-based Rho kinase (ROCK) inhibitors were designed and evaluated. The discovered compounds had excellent enzyme and cellular potency, high kinase selectivity, high aqueous solubility, good porcine corneal penetration, and appropriate DMPK profiles for topical applications as antiglaucoma therapeutics.
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