Brain-Specific Chemical Delivery Systems for β-Lactam Antibiotics. Synthesis and Properties of Some Dihydropyridine and Dihydroisoquinoline Derivatives of Benzylpenicillin

DOI: 10.1021/jm00128a019

Source and publish data:

Journal of Medicinal Chemistry p. 1774 - 1781 (1989)

Update date:2022-08-04

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Authors:

Pop, Emil

Wu, Whei-Mei

Shek, Efraim

Bodor, Nicholas

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Article abstract of DOI:10.1021/jm00128a019

Six chemical delivery systems (CDS) were synthesized for benzylpenicillin in order to improve its transport across the blood-brain barrier.The CDS's were based on a dihydropyridine <-> quaternary pyridinium ion redox system, analogous to the naturally occ

Full text of DOI:10.1021/jm00128a019

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