DIASTEREOSELECTIVE SYNTHESIS OF α-ALKYL-β-HYDROXY THIOACETALS BY CHELATION-CONTROLLED ADDITION TO α-HYDROXY KETENE THIOACETALS

Article abstract of DOI:10.1016/S0040-4039(00)95295-X

Addition of alkyllithiums to (S)-2-(2-hydroxypropylidene)-1,3-dithiane and reduction of (S)-2-(2-hydroxy-1-alkylpropylidene)-1,3-dithianes with lithium aluminium hydride gave optically active syn- and anti-2-(2-hydroxy-1-alkylpropyl)-1,3-dithianes with high diastereoselectivity, respectively.