A double donor-activated Ruthenium(VII) catalyst: Synthesis of enantiomerically pure THF-Diols

Article abstract of DOI:10.1002/anie.200903090

Chemical Equation Presented Double, double, no toll and trouble: Enantiomerically pure tetrahydrofurans are obtained with high position- and stereoselectivity through a ruthenium(Vll)-catalyzed oxidative cyclization of 5,6dihydroxy alkenes (see scheme TPAP = tetrapropylammonium perruthenate). A dual activation modifies the reactivity and increases the carbophilicity of the transition metal so that an otherwise unusual dioxygenation with perruthenate occurs.