Tetrahedron Letters p. 133 - 136 (1993)
Update date:2022-08-03
Topics:
Dolle, Roland E.
McNair, David
A novel series of guanine nucleoside analogues 5-8 which contain a C-terminal sulfoximine have been synthesized.Key features of the synthesis include 1) the successful application of the trifluoroacetyl functional group as a stable, base-labile protecting group for the sulfoximine nitrogen and 2) the Mitsunobu-type coupling of alcohols 14 and 18-20 with purine 15.
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Doi:10.1002/jps.2600560523
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