TABLE 2. 1H NMR Spectra of Compounds 7-16, 29, 33, and 34
Com-
pound
Chemical shifts, δ, ppm (J, Hz)
7
0.39 (2H, m, H c-Pr); 0.58 (2H, m, H c-Pr); 1.19 (1H, m, H c-Pr);
2.48 (2H, d, J = 5.4, CH2-benzyl); 7.01 (2H, m, Н arom);
7.19 (1H, t, J = 8.0, Н arom); 7.25-7.35 (3H, m, Н arom);
7.48 (2H, d, J = 8.0, Н arom); 7.91(1H, m, Н arom); 9.19 (1H, s, NH)
8
9
0.19 (2H, m, H c-Pr); 0.61 (2H, m, H c-Pr); 1.01 (1H, m, H c-Pr);
2.42 (3H, s, CH3); 2.62 (2H, d, J = 4.8, CH2-benzyl); 7.11-7.33 (5H, m, Н arom);
7.76 (2H, d, J = 8.1, Н arom); 7.91 (1H, m, Н arom); 8.93 (1H, s, NH)
0.21 (2H, m, H c-Pr); 0.59 (2H, m, H c-Pr); 0.95 (1H, m, H c-Pr);
2.61 (2H, d, J = 5.2, CH2-benzyl); 7.18 (1H, m, Н arom); 7.23 (1H, m, Н arom);
7.38 (1H, m, Н arom); 7.63 (2H, d, J = 8.2, Н arom); 7.68 (2H, d, J = 8.2, Н arom);
7.89 (1H, m, Н arom); 9.41 (1H, s, NH)
10
11
12
13
14
15
16
29
0.17 (2H, m, H c-Pr); 0.48 (2H, m, H c-Pr); 0.94 (1H, m, H c-Pr);
1.17 (6H, d, J = 6.4, CH(CH3)2); 2.38 (2H, d, J = 5.2, CH2-benzyl);
2.59 (1H, m, CH(CH3)2); 4.22 (4H, m, OCH2CH2O); 6.78 (1H, s, Н arom) and
6.82 (1H, s, Н arom); 8.81 (1H, s, NH)
0.12 (2H, m, H c-Pr); 0.39 (2H, m, H c-Pr); 0.91 (1H, m, H c-Pr);
2.38 (2H, d, J = 5.4, CH2-benzyl); 4.25 (4H, m, OCH2CH2O);
6.77 (1H, s, Н arom); 6.91 (1H, s, Н arom); 7.48-7.59 (3H, m, Н arom);
7.95 (2H, m, Н arom); 9.71 (1H, s, NH)
0.19 (2H, m, H c-Pr); 0.54 (2H, m, H c-Pr); 0.92 (1H, m, H c-Pr);
2.24 (2H, d, J = 5.6, CH2-benzyl); 3.85 (3H, s, OCH3);
4.31 (4H, m, OCH2CH2O); 6.91 (2H, d, J = 8.2, Н arom); 7.06 (1H, s, Н arom);
7.08 (2H, d, J = 8.2, Н arom); 7.12 (1H, s, Н arom); 9.29 (1H, s, NH)
0.16 (2H, m, H c-Pr); 0.47 (2H, m, H c-Pr); 0.97 (1H, m, H c-Pr);
2.42 (3H, s, CH3); 2.48 (2H, d, J = 5.4, CH2-benzyl); 4.26 (4H, m, OCH2CH2O);
6.84 (1H, m, Н arom); 6.86 (1H, s, Н arom); 7.25 (2H, d, J = 8.2, Н arom);
7.86 (2H, d, J = 8.2, Н arom); 9.17 (1H, s, NH)
0.12 (2H, m, H c-Pr); 0.41 (2H, m, H c-Pr); 0.91 (1H, m, H c-Pr);
2.44 (2H, d, J = 5.6, CH2-benzyl); 4.21 (4H, m, OCH2CH2O); 6.81 (1H, s, Н arom);
6.92 (1H, s, Н arom); 7.69 (2H, d, J = 8.4, Н arom); 7.92 (2H, d, J = 8.4, Н arom);
9.54 (1H, s, NH)
0.11 (2H, m, H c-Pr); 0.42 (2H, m, H c-Pr); 0.87 (1H, m, H c-Pr);
2.35 (2H, d, J = 5.6, CH2-benzyl); 4.27 (4H, m, OCH2CH2O); 6.79 (1H, s, Н arom);
6.93 (1H, s, Н arom); 7.34 (2H, d, J = 8.4, Н arom); 8.13 (2H, d, J = 8.4, Н arom);
10.05 (1H, s, NH)
0.21 (2H, m, H c-Pr); 0.56 (2H, m, H c-Pr); 0.93 (1H, m, H c-Pr);
2.14 (2H, d, J = 5.6, CH2-benzyl); 3.78 (3H, s, OCH3); 3.89 (3H, s, OCH3);
3.97 (3H, s, OCH3); 6.91 (2H, d, J = 8.0, Н arom); 7.06 (1H, s, Н arom);
7.08 (2H, d, J = 8.0, Н arom); 7.12 (1H, s, Н arom); 9.31 (1H, c, NH)
1.01 (3H, t, J = 7.2, CH3CH2CH2); 1.76 (2H, m, CH3CH2CH2);
2.97 (2H, t, J = 7.2, CH3CH2CH2); 3.88 (3H, c, CH3O); 4.29 (2H, m, OCH2CH2O);
4.38 (2H, m, OCH2CH2O); 7.02 (2H, d, J = 8.2, Н arom); 7.48 (1H, s, Н arom);
7.92 (2H, d, J = 8.2, Н arom); 8.39 (1H, s, Н arom); 12.04 (1H, c, NH)
33
34
1.15 (6H, d, J = 6.2, CH(CH3)2); 2.58 (1H, m, CH(CH3)2);
3.22 (2H, d, J = 6.4, CH2CH=CH2); 4.21 (4H, m, OCH2CH2O); 5.03 (2H, m, CH2=CH);
5.89 (1H, m, CH2CH=CH2); 6.59 (1H, s, Н arom); 6.85 (1H, s, Н arom); 8.55 (1H, s, NH)
3.27 (2H, d, J = 6.4, CH2CH=CH2); 4.25 (4H, m, OCH2CH2O); 5.11 (2H, m, CH2=CH);
5.88 (1H, m, CH2CH=CH2); 6.65 (1H, s, Н arom); 6.85 (1H, s, Н arom);
7.61 (2H, d, J = 8.2, Н arom); 7.89 (2H, d, J = 8.2, Н arom); 9.45 (1H, s, NH)
H
Me
R
Me
O
O
O
O
+
+
H
H
O
33, 34
O
N
N
R
35, 36
37, 38
33, 35 R = i-Pr, 34, 36 R = p-BrC6H4
1099