Efficient Regioselective Preparation of 2,6-Disubstituted Derivatives of 3-Acetoxy-5,5-dimethyl-2-cyclohexenone

Article abstract of DOI:10.1055/s-1988-27773

Low temperature generation of dianions of 2-alkylated derivatives of dimedone, followed by alkylation at C-4 and quenching of the reaction mixture with acetic anhydride at room temperature furnishes the least sterically hindered 2,6-dialkyl-3-acetoxy-5,5-dimethyl-2-cyclohexenones 2 with high selectivity in a one-pot process.