The α-Bromoester-Imine Condensation promoted by Zinc-Trimethylchlorosilane: A Stereospecific Short Formal Synthesis of (+/-)-Carbapenem Antibiotics and Realated Compounds

DOI: 10.1039/c39890000074

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 74 - 76 (1989)

Update date:2022-09-26

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Authors:

Cossio, Fernando P.

Odrizola, Jose M.

Oiarbide, Mikel

Palomo, Claudio

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Article abstract of DOI:10.1039/c39890000074

Ethyl bromoacetate reacts with imines in the presence of zinc activated by trimethylchlorosilane to give high yields of 3-unsubstituted β-lactams.

Full text of DOI:10.1039/c39890000074

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