Chemical Communications p. 3384 - 3386 (2010)
Update date:2022-08-02
Topics:
Andersson, Hans
Sainte-Luce Banchelin, Thomas
Das, Sajal
Olsson, Roger
Almqvist, Fredrik
Addition of Grignard reagents to pyridine N-oxides in THF at low temperature (-78 to -20 °C) and treatment with TFAA provides an efficient general procedure for synthesis of substituted pyridines. The method is compatible with a range of functional groups such as esters, halogens and nitriles.
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