Total synthesis of malyngamide M and isomalyngamide M

DOI: 10.1016/j.tet.2010.03.004

Source and publish data:

Tetrahedron p. 3499 - 3507 (2010)

Update date:2022-08-02

Topics:

Authors:

Chen, Jie

Shi, Zi-Fa

Zhou, Ling

Xie, An-Le

Cao, Xiao-Ping

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Article abstract of DOI:10.1016/j.tet.2010.03.004

The stereoselective synthesis of malyngamide M (1) was accomplished in nine steps from o-cresol in 12% overall yield. The key steps involved the Wittig reaction of an α-NHBoc aryl ketone 4 for the introduction of vinyl chloride functionality, an amidation

Full text of DOI:10.1016/j.tet.2010.03.004

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