Quinolone antibacterials: Synthesis and biological activity of carbon isosteres of the 1-piperazinyl and 3-amino-1-pyrrolidinyl side chains

DOI: 10.1021/jm00066a005

Source and publish data:

Journal of Medicinal Chemistry p. 1964 - 1970 (1993)

Update date:2022-09-26

Topics:

Authors:

Laborde Laborde

Kiely Kiely

Culbertson

Lesheski

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Article abstract of DOI:10.1021/jm00066a005

A series of 6-fluoro-1,4-dihydro-4-oxo-3-quinoline- and 1,8- naphthyridinecarboxylic acids, substituted at the 7-position with carbon- linked side chains, was synthesized and evaluated for antibacterial activity and DNA-gyrase inhibition. Structural modif

Full text of DOI:10.1021/jm00066a005

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