Cephalosporin 3'-Quinolone Esters with a Dual Mode of Action

Article abstract of DOI:10.1021/jm00163a013

According to the generally accepted mechanism by which bacterial enzymes react with cephalosporins, opening of the β-lactam ring can lead to the expulsion of a 3'-substituent.A series of dual-action cephalosporins was prepared in which antibacterial quino