Desulfation and rearrangement of tigemonam to an isoxazolidin-5-one and the synthesis of the rearrangement product

DOI: 10.1002/jhet.5570260104

Source and publish data:

Journal of Heterocyclic Chemistry p. 17 - 21 (1989)

Update date:2022-08-04

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Authors:

Singh Singh

Kissick Kissick

Fox Fox

Kocy Kocy

Mueller Mueller

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Article abstract of DOI:10.1002/jhet.5570260104

The β-lactam antibiotic Tigemonam undergoes desulfation to the N-hydroxyazetidinone, which rearranges to the isoxazolidin-5-one. the structure of the rearrangement product was confirmed by synthesis.

Full text of DOI:10.1002/jhet.5570260104

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