(E)-4-(α-Halo-p-tolyl)-2-oxo-3-butenoic Acids Inhibit Yeast Pyruvate Decarboxylase by a Diversity of Mechanisms: Multiple Fate for the Thiamin-Bound Enamine Intermediate

DOI: 10.1021/ja00206a019

Source and publish data:

Journal of the American Chemical Society p. 8895 - 8901 (1989)

Update date:2022-08-04

Topics:

Authors:

Annan, Nikoi

Paris, Richard

Jordan, Frank

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/ja00206a019

(E)-4-(p-Tolyl)-2-oxo-3-butenoic acid and its α-(bromomethyl) and α-(chloromethyl) derivatives have been synthesized, and their interaction with brewers' yeast pyruvate decarboxylase was evaluated.The p-tolyl compound was found to be a slow substrate.The

Full text of DOI:10.1021/ja00206a019

Products guided by the article

Product name:p-(Bromomethyl)cinnamaldehyde

Cas No:123333-26-6

R&D Labs maybe for 123333-26-6

JenKem Technology Co., Ltd.

Contact:86-10-62983737; +86-10-51287608

Address:4/F Building C, 2 Shangdi Xinxi Road
Wuhan Chemchemical Co., Ltd.(expird)

Contact:15973022782

Address:7-5-6218,Incubation Centre,Guandong Industry Park, East Lake High-Tech Development Zone,Wuhan City.
GenicBio Limited

Contact:+86-(0)21-3770 9035

Address:Room 301, Building 2, Meijiabang Road 1508, Shanghai China
hangzhou verychem science and technology co.ltd

website:http://www.verypharm.com

Contact:+86-571-88162785; 88162786

Address:F1502, 753 Shenhua road, Hangzhou, China
Esuccess Material Limited

Contact:852-29282288

Address:HONGKONG

Relevant to this article

Decarboxylative Organocatalyzed Addition Reactions of Fluoroacetate Surrogates for the Synthesis of Fluorinated Oxindoles

Doi:10.1021/acs.orglett.1c00172
(2021)
A new, highly efficient, selective methodology for formation of medium-ring and macrocyclic lactones via intramolecular ketene trapping: An application to a convergent synthesis of (-)-kromycin

Doi:10.1021/ja00203a044
(1989)
Palladium catalyzed oxidative Suzuki coupling reaction of indolizine at the 3-position using oxygen gas as the only oxidant

Doi:10.1039/c4ra03799e
(2014)
Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms

Doi:10.1016/j.bmc.2010.04.024
(2010)
Intramolecular cobalt-catalyzed [2+2+2] cycloaddition of o-protected diyne-cyanohydrins

Doi:10.1055/s-0029-1219572
(2010)
Pyrazine biosynthesis in corynebacterium glutamicum

Doi:10.1002/ejoc.201000155
(2010)

Article Doi