(E)-4-(α-Halo-p-tolyl)-2-oxo-3-butenoic Acids Inhibit Yeast Pyruvate Decarboxylase by a Diversity of Mechanisms: Multiple Fate for the Thiamin-Bound Enamine Intermediate

DOI: 10.1021/ja00206a019

Source and publish data:

Journal of the American Chemical Society p. 8895 - 8901 (1989)

Update date:2022-08-04

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Authors:

Annan, Nikoi

Paris, Richard

Jordan, Frank

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Article abstract of DOI:10.1021/ja00206a019

(E)-4-(p-Tolyl)-2-oxo-3-butenoic acid and its α-(bromomethyl) and α-(chloromethyl) derivatives have been synthesized, and their interaction with brewers' yeast pyruvate decarboxylase was evaluated.The p-tolyl compound was found to be a slow substrate.The

Full text of DOI:10.1021/ja00206a019

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