Synthesis of peptidyl fluoromethyl ketones and peptidyl α-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G

DOI: 10.1021/jm00163a063

Source and publish data:

Journal of Medicinal Chemistry p. 394 - 407 (1990)

Update date:2022-08-04

Topics:

Authors:

Peet Peet

Burkhart

Angelastro

Giroux Giroux

Mehdi Mehdi

Bey Bey

Kolb Kolb

Neises Neises

Schirlin

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Article abstract of DOI:10.1021/jm00163a063

Comparison of MeO-Suc-Val-Pro-Phe-CO₂Me (29) and MeO-Suc-Ala-Ala-Pro-Phe-CO₂Me (25) with their corresponding trifluoromethyl ketones 9a and 9b, respectively, in rat and human neutrophil cathepsin G assays showed the α-keto esters to

Full text of DOI:10.1021/jm00163a063

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