Synthesis and Structure-Affinity of a Series of 7α-Undecylestradiol Derivatives: A Potential Vector for Therapy and Imaging of Estrogen-Receptor-Positive Cancers

Article abstract of DOI:10.1021/jm00163a066

A series of 7-α-undecylestradiol derivatives, featuring various substituents at the end of the undecyl spacer chain, were synthesized and evaluated for their interaction with the estrogen receptor and nonreceptor sites.Their relative binding affinities (R