Tetrahedron Letters p. 5364 - 5366 (2012)
Update date:2022-08-03
Topics:
Pan, Xianhua
Huang, Rui
Zhang, Jianshui
Ding, Liping
Li, Weijin
Zhang, Qunhui
Liu, Feng
An efficient synthesis of prasugrel, a novel P2Y12 receptor inhibitor, is described. The cyclopropyl-phenylethanone intermediate was prepared by cyanide substitution, bromination, N-substitution, and the Grignard reaction. After acid hydrolyzation of the methyl ether and subsequent acetylation, the title product was obtained with a total yield of 21% after 10 linear steps from simple and commercially available raw materials.
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