Journal of Organic Chemistry p. 5567 - 5574 (1989)
Update date:2022-07-29
Topics:
Minnetian, Ohannes M.
Morris, Ian K.
Snow, Kevin M.
Smith, Kevin M.
Efficient syntheses of 2,4-dibromo- and 2,4-diiododeuteroporphyrin IX have been carried out by treating zinc(II) 2,4-bis(chloromercurio)deuteroporphyrin IX dimethyl ester (2) with bromine or iodine.Unavoidable mesochlorination occurs when 2 is treated with chlorine and with other free-radical chlorinating agents.Regioselective meso-chlorination and peripheral (β) bromination are shown to occur from brief treatment of copper(II) deuteroperphyrin IX or β-unsubstituted a,c-biladienes with the corresponding copper(II) halide in refluxing dimethylformamide.Protoporphyrin IX has been synthesized by vinylation of 2 via ethylene/LiPdCl3 (35percent yield), with vinyl bromide and Wilkinson's catalyst (63percent), or from 2,4-dibromodeuteroporphyrin IX with ethenyltributylstannane/(Ph3P)4Pd0 (85percent).
View MoreContact:0510-85393305
Address:1619 Huishan Avenue, Huishan District, Wuxi,
Shanghai Yurui Biotechnology(Anyang) Pharmaceutical Co., Ltd
Contact:+86-0372-3662335 +86-0372-3661988
Address:hanling industrial park anyang
Qingdao S. H. Huanyu Imp. & Exp. Co., Ltd.
Contact:86-532-88250866
Address:Room 615, World Trade Centre Building B, Hongkong Middle Roda 6#, Qingdao, Shandong, China
Contact:86-510-82853889
Address:Rm.3732, No.18-2,Yonghe Rd.,Wuxi,Jiangsu,214023,China
Wuxi Innopal International Trade CO.,LTD
Contact:+86-510-80711901-8003
Address:Room 402,Building 5,Longze Garden,No.17,South huanjiu Road,Yixing City, Jiangsu,China
Doi:10.1080/10426500902917651
(2010)Doi:10.1039/c6ob01498d
(2016)Doi:10.1002/jhet.370
(2010)Doi:10.1016/j.ejmech.2010.10.034
(2011)Doi:10.1021/jm100442u
(2010)Doi:10.1002/cjoc.201090130
(2010)