"Umpolung" Using a Phosphorus Group. A Novel Method for the Chemoselective Synthesis of 2-Acetonyl or 3-Acetonyl Morpholines

DOI: 10.1055/s-1989-27232

Source and publish data:

Synthesis p. 301 - 303 (1989)

Update date:2022-08-04

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Authors:

Cristau, H. J.

Fonte, M.

Torreilles, E.

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Article abstract of DOI:10.1055/s-1989-27232

The substituted vinyltriphenylphosphonium salt 1 is shown to undergo chemoselective a⁴ addition with 2-aminoethanols 2 and 3 followed by intramolecular a⁴,a³-cyclization to give novel functionalized morpholines.

Full text of DOI:10.1055/s-1989-27232

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