Enantioselective Construction of a Quaternary Asymmetric Carbon Center: A Versatile Synthesis of α-Alkyl α-Amino Acids

Article abstract of DOI:10.1021/jo00284a004

The enantioselective construction of a quaternary asymmetric carbon center was developed through reaction of the dianions derived from the chiral half esters of monosubstituted malonic acids with 2 molar equi of LDA and alkyl halides.Alkylation in the reverse sequence preferentially gave the same diastereomer.The alkylated half esters were transformed into α-alkyl α-amino acids.