Journal of Organic Chemistry p. 5768 - 5774 (1989)
Update date:2022-08-05
Topics:
Wei, Z. Y.
Wang, D.
Li, J. S.
Allylalkoxysilanes 1 condense with aldehydes under Lewis acid conditions to give cis-2,4,6-trisubstituted tetrahydropyrans 3 or the homoallylic alcohols 2.Factors affecting the reaction have been examined.The enantioselective synthesis of 2 using optically active 1 has also been studied.The reaction is applied to the enantioselective synthesis of (6'-methyl-2'-tetrahydropyranyl)acetic acid (11), a natural compound that has been isolated from the glandular secretion of the civet cat.
View MoreLandz International Company Ltd.
Contact:0086-21-58891610
Address:985 Dongfang Road, Pudong, Shanghai 200122 China
Disynthesis Chemical Technology Co. Ltd.
Contact:+86-571-88194596
Address:Dengyun road 380, Gongshu district, Hangzhou city, China
zhengzhou Triz Pharma-Tech Co., Ltd
website:http://www.Trizpharma-tech.com
Contact:+86-0371-86597269，53392065
Address:High-tech Industrial Development Zone, Zhengzhou City, NO.7 Holly Street
Ningbo Inno Pharmchem Co., Ltd.
Contact:86-574-87319282
Address:6F-5,NO.163 RUIQING RD.,NINGBO 315000 CHINA
Xi'an caijing Opto-Electrical Science & Technology Co., LTD
Contact:+86-29-88294447
Address:NO.168 Zhangba Rd. East, Xi'an, P.R.China
Doi:10.1071/CH10024
(2010)Doi:10.1021/om100345e
(2010)Doi:10.1007/s11172-009-0024-4
(2009)Doi:10.1038/s41557-020-0475-7
(2020)Doi:10.1007/s11172-008-0348-5
(2008)Doi:10.1021/acs.inorgchem.8b02127
(2018)
