
Tetrahedron p. 8285 - 8296 (1991)
Update date:2022-08-04
Topics:
Ley, Steven V.
Trudell, Mark L.
Wadsworth, David J.
A variety of O-methyl-3-acyl tetronates were prepared in good yield from the corresponding acid chlorides via a palladium catalyzed acylation of O-methyl 3-(tri-n-butylstannyl) tetronate 5.This new synthetic method was the exploited for the total synthesis of the novel antibiotic agglomerin A 3a, as well as the fungal metabolite (+/-)-carolinic acid 15.
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