Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines

DOI: 10.1021/jm00169a040

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Journal of Medicinal Chemistry p. 2045 - 2051 (1990)

Update date:2022-09-26

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Authors:

McNamara

Berman Berman

Fry Fry

Werbel Werbel

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Article abstract of DOI:10.1021/jm00169a040

The synthesis and biological activity of two series of nonclassical thymidylate synthase (TS) inhibitors are described. The first is a series of 10-propargyl-5.8-dideazafolic acid derivatives (10a-j) and the second is a series of the analogous 2-desamino

Full text of DOI:10.1021/jm00169a040

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