Novel Prodrugs Which Are Activated to Cytotoxic Alkylating Agents by Carboxypeptidase G2

DOI: 10.1021/jm00164a034

Source and publish data:

Journal of Medicinal Chemistry p. 677 - 681 (1990)

Update date:2022-07-29

Topics:

Authors:

Springer, Caroline J.

Antoniw, Pari

Bagshawe, Kenneth D.

Searle, Frances

Bisset, Graham M. F.

Jarman, Michael

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Article abstract of DOI:10.1021/jm00164a034

The synthesis of three novel prodrugs, 4-amino>benzoyl-L-glutamic acid (7), 4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>benzoyl-L-glutamic acid (8), and 4-benzoyl-L-glutamic acid (9), for use as anticancer ag

Full text of DOI:10.1021/jm00164a034

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Product name:di-tert-butyl 4-benzoyl-L-glutamate

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