Journal of Medicinal Chemistry p. 673 - 677 (1990)
Update date:2022-09-26
Topics:
DeGraw, Joseph I.
Christie, Pamela H.
Kisliuk, Roy L.
Gaumont, Yvette
Sirotnak, Francis M.
Synthesis of the 10-methyl and 10-ethyl analogues of 5,10-dideazatetrahydrofolic acid (DDTHF), a potent inhibitor of glycinamide ribotide (GAR) formyltransferase, is reported.Key intermediates in the process were 10-methyl- and 10-ethyl-4-amino-4-deoxy-5,
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