&γ-AMINO &α-ACETYLENIC EPOXIDES. Preparation and biological activity due to an aldehyde reductase inhibition

DOI: 10.1016/0040-4020(89)80141-3

Source and publish data:

Tetrahedron p. 1429 - 1440 (1989)

Update date:2022-08-04

Topics:

Authors:

Bernard, Didier

Doutheau, Alain

Gore, Jacques

Moulinoux, Jacques

Quemener, Veronique

et al. et al.

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Article abstract of DOI:10.1016/0040-4020(89)80141-3

The preparation of several of the entitled epoxides 3 is described in two steps starting from 2-methyl 2-amino but 3-yne, the first one being the reaction of the lithium acetylide with a α-chloroaldehyde or ketone.In certain cases, this reaction is highly

Full text of DOI:10.1016/0040-4020(89)80141-3

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