Synthesis of functionalized 3-hydroxypiperidines

DOI: 10.1016/j.tet.2010.05.089

Source and publish data:

Tetrahedron p. 5623 - 5636 (2010)

Update date:2022-08-02

Topics:

Authors:

Wijdeven, Marloes A.

Van Delft, Floris L.

Rutjes, Floris P.J.T.

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Article abstract of DOI:10.1016/j.tet.2010.05.089

The synthetic versatility of three chemoenzymatically prepared hydroxypiperidine building blocks has been explored, resulting in a library of enantiopure functionalized piperidines. Key steps involved N-acyliminium ion-mediated CC-bond formation and cross-metathesis reactions, after which full deprotection led to the set of free 3-hydroxypiperidines.

Full text of DOI:10.1016/j.tet.2010.05.089

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