Journal of Medicinal Chemistry p. 31 - 38 (1990)
Update date:2022-08-02
Topics: Inhibitors Cholesterol Biosynthesis 1,3,5-Trisubstituted
Sliskovic
Roth
Wilson
Hoefle
Newton
A series of 1,3,5-trisubstituted pyrazole mevalonolactones were prepared and evaluated for their ability to inhibit the enzyme HMG-CoA reductase in vitro. Since previous studies suggested that the 5-(4-fluorophenyl) and 3-(1-methylethyl) substituents affo
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