Bulletin of the Chemical Society of Japan p. 674 - 681 (1989)
Update date:2022-09-26
Topics:
Kuroda, Tokuyuki
Hisamura, Koji
Matsukuma, Ikuo
Nishikawa, Hiroshi
Nakamizo, Nobuhiro
A new concept, "Radiation-Induced Drug (RID)", was proposed as a novel type of drugs for cancer therapy.To test the usefulness of this concept, 5-fluorouracil (5-FU) derivatives having various types of substituents at the 1-position were prepared and the γ-radiolyses of their aqueous solutions were studied.The compounds having sulfonyl and thioureido groups as the substituents produced efficiently 5-FU with high G valus upon γ-irradiation.The medium effects on the radiolyses revealed that the above two substituents were removed mainly with HO. and hydrated electrons e-eq.
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