Bulletin of the Chemical Society of Japan p. 674 - 681 (1989)
Update date:2022-09-26
Topics:
Kuroda, Tokuyuki
Hisamura, Koji
Matsukuma, Ikuo
Nishikawa, Hiroshi
Nakamizo, Nobuhiro
A new concept, "Radiation-Induced Drug (RID)", was proposed as a novel type of drugs for cancer therapy.To test the usefulness of this concept, 5-fluorouracil (5-FU) derivatives having various types of substituents at the 1-position were prepared and the γ-radiolyses of their aqueous solutions were studied.The compounds having sulfonyl and thioureido groups as the substituents produced efficiently 5-FU with high G valus upon γ-irradiation.The medium effects on the radiolyses revealed that the above two substituents were removed mainly with HO. and hydrated electrons e-eq.
View MoreContact:+8613400661290
Address:No 908,Kangwan Rd, Liuyang Economic
Henan Yellow River New Material Technology Co.Ltd.
website:http://www.yellowriverchem.com
Contact:0086-373-7278760
Address:Chengguan Town, Yuanyang County
website:http://www.amadischem.com
Contact:86-571-89925085
Address:Watts Cosine.No.166.Xiangmao Road.
Ningbo Distant Chemicals Co.,Ltd
Contact:86-574-27862490,27862438
Address:5F-3,#54 DaShaNi street,Ningbo,CHINA
Hefei TNJ chemical industry co.,ltd
website:https://www.tnjchem.com
Contact:+86-551-65418695
Address:B911 Xincheng Business Center, Qianshan Road, Hefei Anhui China
Doi:10.1016/j.ejmech.2010.05.051
(2010)Doi:10.1016/j.tetasy.2010.03.045
(2010)Doi:10.1021/ja106632j
(2010)Doi:10.1021/acs.orglett.8b01377
(2018)Doi:10.1016/S0040-4039(01)80412-3
(1989)Doi:10.1007/BF00633516
(1988)