Bulletin of the Chemical Society of Japan p. 674 - 681 (1989)
Update date:2022-09-26
Topics:
Kuroda, Tokuyuki
Hisamura, Koji
Matsukuma, Ikuo
Nishikawa, Hiroshi
Nakamizo, Nobuhiro
A new concept, "Radiation-Induced Drug (RID)", was proposed as a novel type of drugs for cancer therapy.To test the usefulness of this concept, 5-fluorouracil (5-FU) derivatives having various types of substituents at the 1-position were prepared and the γ-radiolyses of their aqueous solutions were studied.The compounds having sulfonyl and thioureido groups as the substituents produced efficiently 5-FU with high G valus upon γ-irradiation.The medium effects on the radiolyses revealed that the above two substituents were removed mainly with HO. and hydrated electrons e-eq.
View MoreCeresking Ecology & Technology co.,ltd
Contact:86 22 66218397
Address:Room 1613, Zheshang Mansion, No. 1988, Yingbin Avenue, Binhai New District, Tianjin,China.
wuxi huabin bio-tech Co.,Ltd(expird)
Contact:86-0510-85133006
Address:hubin road NO157
Ningbo Hi-tech Zone Nice-Synth Chemical Industry Ltd.
Contact:+86-(574)-81110986
Address:No. 1210, Building 3, Wante Business Centre, Hi-tech Zone, Ningbo
Jiaxing Carry Bio-Chem Technology Co.,Ltd
website:http://www.carrybiotech.com
Contact:0573-82788958
Address:Add.Fl 3th, Pharm Vally,Kaichuang Rd, Xiuzhou District, Jiaxing, Zhejiang,314031,China
Beijing Zhongshuo Pharmaceutical T & D Co.,Ltd
Contact:0086-10-64430626
Address:ea No 16, HEPINGLI,DONGCHENG DISTRICT,BEIJING,P.R.CHINA.
Doi:10.1016/j.ejmech.2010.05.051
(2010)Doi:10.1016/j.tetasy.2010.03.045
(2010)Doi:10.1021/ja106632j
(2010)Doi:10.1021/acs.orglett.8b01377
(2018)Doi:10.1016/S0040-4039(01)80412-3
(1989)Doi:10.1007/BF00633516
(1988)