Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 2. Derivatives of 7-(1H-Pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) Acids

DOI: 10.1021/jm00163a011

Source and publish data:

Journal of Medicinal Chemistry p. 61 - 70 (1990)

Update date:2022-09-26

Topics:

Authors:

Jendralla, H.

Baader, E.

Bartmann, W.

Beck, G.

Bergmann, A.

et al. et al.

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Article abstract of DOI:10.1021/jm00163a011

A series of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoates (-heptanoates) 1 and 2 have been prepared and tested for inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.The most potent compounds exceeded mevinolin's activity in vitro and in vivo.

Full text of DOI:10.1021/jm00163a011

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