Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 2. Derivatives of 7-(1H-Pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) Acids

DOI: 10.1021/jm00163a011

Source and publish data:

Journal of Medicinal Chemistry p. 61 - 70 (1990)

Update date:2022-09-26

Topics:

Authors:

Jendralla, H.

Baader, E.

Bartmann, W.

Beck, G.

Bergmann, A.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00163a011

A series of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoates (-heptanoates) 1 and 2 have been prepared and tested for inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.The most potent compounds exceeded mevinolin's activity in vitro and in vivo.

Full text of DOI:10.1021/jm00163a011

Products guided by the article

Product name:N,N-bis<3-(4-fluorophenyl)-4-(methoxycarbonyl)-5-methyl-2,3-dihydrofuran-2-yl>hydroxylamine

Cas No:124401-37-2

R&D Labs maybe for 124401-37-2

Shanghai PengMo Biotechnology Co.,Ltd

website:http://www.pengmobio.lookchem.com

Contact:86-13052359378

Address:No.218 Hai Qu Road.Shanghai.China
Jining tiansheng chemical co.,ltd.

Contact:+86-537-5158722

Address:ROOM 1011, BLOCK B, CUIDU INTERNATIOAL BUSINESS CENTER, JINING CITY, CHINA
JiYi Chemical (Beijing) Co., Ltd.

Contact:+86-10-89385733

Address:Shilou Town of Fangshan District， Beijing
Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

website:http://www.jlpharms.com

Contact:86-571-86982636

Address:Rm A606, Fuyi Center, jianqiao street
Dongtai Xinyuan Chemical Co., Ltd.

Contact:+86-21-56733000

Address:404F, 99Nong No.117 Zhongtan Rd. Shanghai

Relevant to this article

Synthesis and in vitro antitumor activities of novel 4-anilinoquinazoline derivatives

Doi:10.1016/j.ejmech.2008.07.023
(2009)
Chiral tetraphenylethenes as novel dopants for calamitic and discotic liquid crystals

Doi:10.1002/poc.1506
(2009)
Synthesis and in vitro antibacterial activity of 7-(4-alkoxyimino-3-amino-3-methylpiperidin-1-yl)fluoroquinolone derivatives

Doi:10.1016/j.ejmech.2009.04.041
(2009)
Doi:10.1021/jo00959a045
(1973)
Novel Synthesis of Pyrrolidinones by Cobalt Carbonyl Catalyzed Carbonylation of Azetidines. A New Ring-Expansion-Carbonylation Reaction of 2-Vinylazetidines to Tetrahydroazepinones

Doi:10.1021/ja00201a040
(1989)
Optical Resolution of 2'-Methoxy-1,1'-binaphthyl-2-carboxylic Acid, and Application to Chiral Derivatizing Agent for HPLC Separation of Enantiomeric Alcohols and Amines

Doi:10.1246/bcsj.62.1528
(1989)

Article Doi