Journal of Medicinal Chemistry p. 61 - 70 (1990)
Update date:2022-09-26
Topics:
Jendralla, H.
Baader, E.
Bartmann, W.
Beck, G.
Bergmann, A.
et al.
A series of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoates (-heptanoates) 1 and 2 have been prepared and tested for inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.The most potent compounds exceeded mevinolin's activity in vitro and in vivo.
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