Formal nucleophilic substitution of bromocyclopropanes with amides en route to conformationally constrained β-amino acid derivatives

DOI: 10.1021/ol101228k

Source and publish data:

Organic Letters p. 3968 - 3971 (2010)

Update date:2022-09-26

Topics: Amides Nucleophilic substitution β-amino acid derivatives Conformationally constrained

Authors:

Prosser, Anthony R.

Banning, Joseph E.

Rubina, Marina

Rubin, Michael

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Article abstract of DOI:10.1021/ol101228k

A chemo- and diastereoselective protocol for the formal nucleophilic substitution of 2-bromocyclopropylcarboxamides with secondary amides is described. This method allows for convergent and highly selective synthesis of trans-β-aminocyclopropane carboxylic acid derivatives.

Full text of DOI:10.1021/ol101228k

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