Organocatalyst-mediated enantioselective intramolecular Michael addition of aldehydes to vinyl sulfones

DOI: 10.1016/j.tetasy.2010.03.043

Source and publish data:

Tetrahedron Asymmetry p. 1666 - 1673 (2010)

Update date:2022-08-04

Topics:

Authors:

Bournaud, Chloee

Marchal, Estelle

Quintard, Adrien

Sulzer-Mosse, Sarah

Alexakis, Alexandre

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Article abstract of DOI:10.1016/j.tetasy.2010.03.043

Chiral amines with a hydrogen bond donor promote the intramolecular conjugate addition of aldehydes to vinyl sulfones. Chiral cyclic sulfone-aldehydes are obtained in good yields with an ee of up to 82%.

Full text of DOI:10.1016/j.tetasy.2010.03.043

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