Synthesis and antitumor activity of 20(S)-camptothecin derivatives. A-ring-substituted 7-ethylcamptothecins and their E-ring-modified water-soluble derivatives

DOI: 10.1248/cpb.42.2518

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2518 - 2525 (1994)

Update date:2022-08-04

Topics:

Authors:

Yaegashi

Sawada Sawada

Nagata Nagata

Furuta Furuta

Yokokura

Miyasaka

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Article abstract of DOI:10.1248/cpb.42.2518

Twenty-six novel A-ring-modified 7-ethylcamptothecins (6) were synthesized by Friedlander's condensation of the chiral tricyclic ketone (5) with aminopropiophenones (4). The compounds substituted with fluorine at the 11 position showed strong cytotoxicity

Full text of DOI:10.1248/cpb.42.2518

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