Synthesis and antitumor activity of 20(S)-camptothecin derivatives. A-ring-substituted 7-ethylcamptothecins and their E-ring-modified water-soluble derivatives

DOI: 10.1248/cpb.42.2518

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2518 - 2525 (1994)

Update date:2022-08-04

Topics:

Authors:

Yaegashi

Sawada Sawada

Nagata Nagata

Furuta Furuta

Yokokura

Miyasaka

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.42.2518

Twenty-six novel A-ring-modified 7-ethylcamptothecins (6) were synthesized by Friedlander's condensation of the chiral tricyclic ketone (5) with aminopropiophenones (4). The compounds substituted with fluorine at the 11 position showed strong cytotoxicity

Full text of DOI:10.1248/cpb.42.2518

NII-Electronic Library Service

Products guided by the article

Product name:2-amino-4-fluoropropiophenone

Cas No:124623-09-2

R&D Labs maybe for 124623-09-2

Shanghai Mio Chemical Co., Ltd

Contact:0086 21- 64401188-622

Address:16 Floor NO.2 Jiefang Building, No. 4855 Dushi Road, 201100 Shanghai, P.R.China
Hubei Xinghuo Chemical Co., Ltd.,

Contact:13925817279 13907299441

Address:Xinghuo Fine Chemistry Industrial Park, Xiaochang County, Hubei Province, China
Sinoway Industrial Co., Ltd.

website:http://www.china-sinoway.com

Contact:+86-592-5853819

Address:16/F,Huicheng Comm,Complex,No839 XiaHe Rd, Xiamen,China
Suzhou Wedo Chemicals Co., Ltd.

Contact:86 512 58100425

Address:Zonger Road, DongSha Industry Park , Zhangjiagang, Jiangsu, China
henan victory industry co.ltd

Contact:86-371-63655023

Address:No.85,jinshui road,zhengzhou,China

Relevant to this article

SYNTHESIS OF 5-SUBSTITUTED NUCLEOSIDES VIA THE REGIOSELECTIVE LITHIATION OF 2'-DEOXYURIDINE

Doi:10.1016/S0040-4039(01)93710-4
(1989)
Synthesis of substituted indoles from 2-azidoacrylates and ortho-silyl aryltriflates

Doi:10.1021/ol101934v
(2010)
Study of new mononuclear platinum group metal complexes containing η⁵ and η⁶ - Carbocyclic ligands and nitrogen based derivatives and formation of helices due to NH?Cl interactions

Doi:10.1016/j.molstruc.2010.06.028
(2010)
Synthesis of kaempferol 3- O -(3″,6″-Di- O - E - p -coumaroyl)-β- D -glucopyranoside, efficient glycosylation of flavonol 3-OH with glycosyl o -alkynylbenzoates as donors

Doi:10.1021/jo1014189
(2010)
Iron-catalyzed direct C-H arylation of heterocycles and quinones with arylboronic acids

Doi:10.1002/ejoc.201300743
(2013)
Microwave-assisted synthesis of 1,3-dialkyl ethers of calix[4]arenes: Application to the synthesis of cesium selective calix[4]crown-6 ionophores

Doi:10.1016/j.tetlet.2011.10.142
(2012)

Article Doi