SYNTHESIS OF 5-SUBSTITUTED NUCLEOSIDES VIA THE REGIOSELECTIVE LITHIATION OF 2'-DEOXYURIDINE

DOI: 10.1016/S0040-4039(01)93710-4

Source and publish data:

Tetrahedron Letters p. 2057 - 2060 (1989)

Update date:2022-08-04

Topics:

Authors:

Armstrong, Robert W.

Gupta, Saaket

Whelihan, Fayelle

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Article abstract of DOI:10.1016/S0040-4039(01)93710-4

Treatment of 2'-deoxy-3',5'-bis-O-<(1,1-dimethylethyl)dimethylsilyl>-uridine with sec-BuLi in the presence of TMEDA resulted in a highly regioselective lithiation at C-5.The lithiated derivative was treated with a number of electrophiles to afford 5-substituted 2'-deoxyuridines.

Full text of DOI:10.1016/S0040-4039(01)93710-4

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