The principles of Tetragonia tetragonoides having anti-ulcerogenic activity. II. Isolation and structure of cerebrosides

DOI: 10.1248/cpb.31.2209

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2209 - 2219 (1983)

Update date:2022-08-05

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Authors:

Okuyama Okuyama

Yamazaki

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Article abstract of DOI:10.1248/cpb.31.2209

Compound B₁ (tentative name), isolated from Tetrogonia tetragonoides as a principle with anti-ulcerogenic activity, was determined to be a mixture of geometrical isomers of 1-O-β-D-glucopyranosyl-2-N-2'-hydroxypalmitoyl-sphinga-4,8-dienine on the basis of chemical and spectral evidence. By repeated chromatography, compound B₁ was separated into compounds B(1-a) (major) and B(1-b) (minor), which were found to be the 4-trans-8-trans and 4-trans-8-cis isomers, respectively. Several cerebrosides and glycolipids from various biological sources were examined for protective activity against the ulcer formation in mice under restraint and water immersion condition.

Full text of DOI:10.1248/cpb.31.2209

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