Selective Inhibition of γ-Aminobutyric Acid Aminotransferase by (3R,4R),(3S,4S)- and (3R,4S),(3S,4R)-4-Amino-5-fluoro-3-phenylpentanoic Acids

DOI: 10.1021/jm00165a008

Source and publish data:

Journal of Medicinal Chemistry p. 931 - 936 (1990)

Update date:2022-09-26

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Authors:

Silverman, Richard B.

Nanavati, Shrenik M.

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Article abstract of DOI:10.1021/jm00165a008

(3R,4R),(2S,4S)- and (3R,4S),(3S,4R)-4-amino-5-fluoro-3-phenylpentanoic acid (1a and 1b) were synthesized and studied as selective inactivators of γ-aminobutyric acid (GABA) aminotransferase.Neither compound caused time-dependent inactivation of the enzym

Full text of DOI:10.1021/jm00165a008

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