Methodology for the Synthesis of Phosphorus-Activated Tetramic Acids: Applications to the Synthesis of Unsaturated 3-Acyltetramic Acids

Article abstract of DOI:10.1021/jo00135a041

A general method is described for the preparation of phosphonate-activated 3-acetyltetramic acids from a variety of α-amino esters, which can serve as precursors of enoyl and dienoyl tetramic acids which are found in a number of natural products.