DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: Consequences of varying the reactivity of the mustard

DOI: 10.1021/jm00166a015

Source and publish data:

Journal of Medicinal Chemistry p. 1177 - 1186 (1990)

Update date:2022-08-04

Topics:

Authors:

Gourdie Gourdie

Valu Valu

Gravatt Gravatt

Boritzki

Baguley Baguley

Wakelin Wakelin

Wilson Wilson

Woodgate

Denny Denny

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00166a015

A series of DNA-targeted aniline mustards have been prepared, and their chemical reactivity and in vitro and in vivo cytotoxicity have been evaluated and compared with that of the corresponding simple aniline mustards. The alkylating groups were anchored

Full text of DOI:10.1021/jm00166a015

Products guided by the article

Product name:7-(4-Amino-phenyl)-heptanoic acid methyl ester

Cas No:125173-88-8

R&D Labs maybe for 125173-88-8

Ningbo Inno Pharmchem Co., Ltd.

Contact:86-574-87319282

Address:6F-5,NO.163 RUIQING RD.,NINGBO 315000 CHINA
ShenZhen InnoSyn Biotech Co.,Ltd

website:http://www.innosyns.com

Contact:+86-755-28351685

Address:Floor 5 & 6, Building A1, HAIKEXING Strategic Innovative Industrial Park, 16 BaoShan Road, PingShan District
Anhui Gusheng Import&Export CO.,LTD

Contact:86-551-63662296

Address:Jinzhai Road NO.162 ,hefei, china
Nantong Auxin Electronic Technology Co., LTD

Contact:86-513-88760026

Address:NO.5-1, Aoxin Road, Haian Hi-tech Development Zone, Jiangsu Province, China
Chemtrade International ( China )

Contact:+86-532-86893005

Address:Rm 2-501, Huaxia Zonghe Building, No. 410 JInggangshan Road, Huangdao

Relevant to this article

Total synthesis of gobiusxanthin stereoisomers and their application to determination of absolute configurations of natural products: Revision of reported absolute configuration of epigobiusxanthin

Doi:10.3390/md13010159
(2015)
New magnetically active metal complexes of tridentate Schiff bases of phenylazosalicylaldehyde

Doi:10.1134/S1070328409070045
(2009)
Study of on-resin convergent synthesis of N-linked glycopeptides containing a large high mannose N-linked oligosaccharide

Doi:10.1021/ja9104073
(2010)
A CONVENIENT AND STEREOSELECTIVE CONVERSION OF ALDEHYDES INTO β-BROMOVINILOXIRANES MEDIATED BY CHROMIUM(II) CHLORIDE

Doi:10.1016/S0040-4039(00)82277-7
(1988)
Synthesis of Scyphostatin Analogues through Hypervalent Iodine-Mediated Phenol Dearomatization

Doi:10.1021/acs.joc.7b02366
(2017)
Interaction of the electrophilic bis(pentafluorophenyl)iodonium cation [(C₆F₅)₂I]⁺ with the ambident pseudohalogenide anions [SCN]^- and [CN]^-

Doi:10.1016/j.jfluchem.2014.04.006
(2014)

Article Doi