DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: Consequences of varying the reactivity of the mustard

DOI: 10.1021/jm00166a015

Source and publish data:

Journal of Medicinal Chemistry p. 1177 - 1186 (1990)

Update date:2022-08-04

Topics:

Authors:

Gourdie Gourdie

Valu Valu

Gravatt Gravatt

Boritzki

Baguley Baguley

Wakelin Wakelin

Wilson Wilson

Woodgate

Denny Denny

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Article abstract of DOI:10.1021/jm00166a015

A series of DNA-targeted aniline mustards have been prepared, and their chemical reactivity and in vitro and in vivo cytotoxicity have been evaluated and compared with that of the corresponding simple aniline mustards. The alkylating groups were anchored

Full text of DOI:10.1021/jm00166a015

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