Journal of Medicinal Chemistry p. 10946 - 10971 (2020)
Update date:2022-08-15
Topics:
Sniecikowska, Joanna
Gluch-Lutwin, Monika
Bucki, Adam
Wi?ckowska, Anna
Siwek, Agata
Jastrzebska-Wiesek, Magdalena
Partyka, Anna
Wilczyńska, Daria
Pytka, Karolina
Latacz, Gniewomir
Przejczowska-Pomierny, Katarzyna
Wyska, El?bieta
Weso?owska, Anna
Paw?owski, Maciej
Newman-Tancredi, Adrian
Kolaczkowski, Marcin
Novel 1-(1-benzoylpiperidin-4-yl)methanamine derivatives with high affinity and selectivity for serotonin 5-HT1A receptors were obtained and tested in four functional assays: ERK1/2 phosphorylation, adenylyl cyclase inhibition, calcium mobilization, and β-arrestin recruitment. Compounds 44 and 56 (2-methylaminophenoxyethyl and 2-(1H-indol-4-yloxy)ethyl derivatives, respectively) were selected as biased agonists with highly differential "signaling fingerprints"that translated into distinct in vivo profiles. In vitro, 44 showed biased agonism for ERK1/2 phosphorylation and, in vivo, it preferentially exerted an antidepressant-like effect in the Porsolt forced swimming test in rats. In contrast, compound 56 exhibited a first-in-class profile: it preferentially and potently activated β-arrestin recruitment in vitro and potently elicited lower lip retraction in vivo, a component of "serotonergic syndrome". Both compounds showed promising developability properties. The presented 5-HT1A receptor-biased agonists, preferentially targeting various signaling pathways, have the potential to become drug candidates for distinct central nervous system pathologies and possessing accentuated therapeutic activity and reduced side effects.
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