Synthetic studies on cytotoxic macrolides cruentarens A and B: Stereoselective synthesis of the C8C19 segment of cruentarens A and B

Article abstract of DOI:10.1016/j.tetasy.2010.04.068

A stereoselective synthesis of the C₈C₁₉ segment of cruentarens A and B, cytotoxic natural products, has been accomplished. The key steps involve a stereoselective radical cyclization, stereospecific methylation of a c, d-epoxy acrylate, nucleophilic epoxide ring opening and a cis-Wittig olefination.